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Europass curriculum vitae |
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updated: 04 2021 |
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Personal information |
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Surname(s) / First name(s) |
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Aleksandar Gj. Cvetkovski, BSc, MSc. (Pharm. Sci&Technology), PhD/DSc. (Structural, Computational & Physical Chemistry) |
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Address(es) |
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Blagoj Davkov 1, 4/15, 1000 Skopje, R. N. Macedonia |
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Cell Phone |
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+ (389) 78 363345 |
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E-mail(s) |
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Nationality(-ies) |
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Macedonian |
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Date of birth |
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13 May1971, Kumanovo (R. N. Macedonia) |
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Gender |
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male |
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Occupational field |
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Crystallographic study on Non-covalent intermolecular interactions (H-bonding) in solid-state systems relevant to pharmaceutical, biomedical and life-sci. applications, Processing of solid systems for pharmaceutical applications, Preformulation & Formulation of Drug-delivery systems |
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Dates |
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March 2021 - ongoing |
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Occupation or position held |
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Assoc. Professor, State University Goce Delcev, Stip R.N. Macedonia; www.ugd.edu.mk |
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Type of business or sector |
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Academics/ University |
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Experiencias/ skills
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Teaching academic courses: Physical Chemistry, Pharmaceutical Technology, Industrial Pharmacy, Medical Devices |
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Dates |
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April 2016 – March 2021 |
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Occupation or position held |
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Ass. Professor, State University Goce Delcev, Stip R.N. Macedonia; www.ugd.edu.mk |
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Type of business or sector |
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Academics/ University |
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Experiencias/ skills
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Teaching academic courses: Physical Chemistry, Pharmaceutical Technology, Bioorganic Chemistry |
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Dates |
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2009 - 2015 |
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Occupation or position held |
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Researcher & Teaching Assistant, State University Goce Delcev, Stip, Macedonia; www.ugd.edu.mk |
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Type of business or sector |
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Academics/ University |
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Experiencias/ skills |
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Teaching Lab Courses: Physical Chemistry, Pharmaceutical Technology, Bioorganic Chemistry |
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Dates |
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2005-2008 |
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Occupation or position held |
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Engineering Expert for Life Science Sectors (Biomedical, Pharmaceutical, Health Care) |
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Main activities and responsibilities
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- Project Manager for Investment studies (Managing Feasibility Studies for investment in Pharma/ Life Sci. Sectors, Promotion of the Venturing in Technology, Policies for High-Tech Life Sci. Industries): - Head of Technology Transfer Program (IPR, Technology Acquisition) |
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Name and address of employer |
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GOIC (Gulf Organization for Industrial Consulting) www.goic.org.qa, Doha, Qatar |
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Type of business or sector |
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Consulting Authority for Investments, founded in Doha (Qatar) by the governments of the six GCC countries |
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Dates |
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2003 –2005 |
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Occupation or position held |
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Advisor for R&D and Production |
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Main activities and responsibilities |
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Development of formulation and production activities for generic pharmaceuticals, cosmetics, chemicals and functional food - Scaling-up form R&D to commercial batches; - Setting-up criteria quality specification for Active Pharmaceutical Ingredient, Excipients and Packing Materials; - Production processes optimization; - Specification for Manufacturing Equipment & Machinery (SAT/ FAT testing –Commissioning), - Process & Facilities Validation (IQ, OQ, PQ); - Regulatory Affairs/ Licensing |
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Name and address of employer |
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JAKA 80, AD, pharmaceutical, cosmetics and dietetic company, Macedonia, |
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Type of business or sector |
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Operational/Manufacturing company dealing in pharmaceutical, chemical and food sector |
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Dates |
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1999 – 2003 |
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Occupation or position held |
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Head of Production Plant for Manufacturing Pharmaceutical Products |
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Main activities and responsibilities |
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- Processes/ Formulation Technology Transfer, - Licensing, Managing Manufacturing operations for Solid Dosage Forms: Tablets & Capsules (Granulation, Tableting, Powders Processing/ Mixing, Handling, Filling, Packaging), Liquids and Pharmaceutical Ointments& Creams, - Process & Facilities Validation (IQ, OQ, PQ), - Start-up, Commissioning of the Production Facilities |
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Name and address of employer |
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ICN Macedonia, Joint venture between ICN Pharmaceutical (US) and OHIS (Organic Chemical Industry-Skopje, Macedonia) |
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Type of business or sector |
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Manufacturer of generic pharmaceuticals |
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Dates |
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1996 – 1998 |
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Occupation or position held |
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Associate for Quality Assurance in Multidisciplinary Team in charge for performing Feasibility Studies & General Engineering Projects for Investment in Pharmaceutical Manufacturing Sectors |
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Main activities and responsibilities |
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- Laying-out for Pharmaceutical Manufacturing Plants - Clean Room Technology; - Disposition of the Processing Lines; - Material-flow diagrams; GMP/ GLP - Requirements for Pharmaceutical Industry (specification for installation for utilities and manufacturing machinery for production of pharmaceutical products) - Validation Master Plan, - Regulatory Affairs (FDA/ EU GMP-GLP) |
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Name and address of employer |
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IRIK – R&D, Strategic Investment, Engineering, and QC Department of OHIS-Organic Chemical Industry Skopje, Macedonia |
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Type of business or sector |
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Consulting for strategic investments, performing, execution, and supervising of engineering projects. Consulting in Quality Management, research services for chemical/ pharmaceutical industry |
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Education and training |
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Dates |
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January 2012 – April 2015 |
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Title of qualification awarded |
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PhD in Structural, Computational & Physical chemistry |
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Principal subjects/Occupational skills covered |
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Crystallography, Solid-state of pharmaceuticals |
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Name and type of organisation providing education and training |
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Centre of Structural Diffrractometry, Department of Chemical & Pharmaceutical Science, Ferrara University (http://scf.unife.it www.unife.it ) , Italy, Tutor : Prof. P.Gilli (www.ggilli.com ) |
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Title of the Thesis |
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Molecular cocrystals of pharmaceutical relevance; www.eprints.unife.it/1040 Part of the Research Project "Hydrogen bonding, halogen bonding and charge-transfer interactions as aggregation forces in molecular crystals and co-crystals, functional materials, and drug-receptor interactions" part of joint-project "Optimization of the molecular and crystal forms of drugs, herbal-drugs, and pesticides in relation to their activity, bioavailability, patentability, and to the production of polymorphs, solvates, and co-crystals by means of green methodologies" granted by the Region Emilia Romagna (Consorzio SPINNER) within the framework of the inter-university network organized by four laboratories of the Universities of Parma, Bologna, Modena, and Ferrara.
Techniques: X-Ray Diffractometry (Absolut Crystal Structure Determination), Intermolecular Interactions/ Recognitions; Multicomponent Crystals/ Cocrystals; Techniques for Crystal Growth/ Crystallization
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Dates |
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28/08-06/09 2014 at Pavia, Italy |
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Title of qualification awarded |
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Trainee |
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Principal subjects/Occupational skills covered |
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Crystallography (Crystal Structure Determination), Techniques for Growing Crystals |
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Name and type of organisation providing education and training |
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1st European Crystallography School, University of Pavia, http://ecs1.azuleon.org
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Dates |
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October-December 2011 |
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Title of qualification awarded |
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Visiting Researcher, Coimbra Group Schollarship awarded researcher, www.coimbra-group.eu
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Principal subjects/Occupational skills covered |
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Project “Printable Drug Delivery Systems”, Development of pharmaceutical formulations, |
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Name and type of organisation providing education and training |
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Pharmaceutical Sci. Laboratory, Abo Akademi University, Turku/ Abo, Finland, (Prof. Niklas Sandler) http://www.abo.fi/fakultet/en/farmaciforskning
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Dates |
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1999-2002 |
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Title of qualification awarded |
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Master of Pharmaceutical Science & Technology |
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Principal subjects/Occupational skills covered |
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New dosage forms, improve bioavailability of pharmaceutical products, |
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Name and type of organisation providing education and training |
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University in Belgrade (Serbia) in collaboration with Parma University (Italy) |
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Level in national or international classification |
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Research Thesis (experimental work done in Lab of Solid State Characterization of Pharmaceuticals, Pharmaceutical Department, Parma University (Italy) Thesis Title: “Preformulation Study on the Pseudopolimorph forms of Carbamazepin and Influence of beta-Cyclodextrin on the Phase Transition” September 2000 - May 2001 |
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Dates |
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1990-1995 |
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Title of qualification awarded |
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Bachelor of Science (BSc.) in Pharmaceutics, |
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Name and type of organisation providing education and training |
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State University Ss “Cyril and Methodius”, Skopje, Macedonia |
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Personal skills and competences |
Macedonian language – native English – professional Italian – basic Turkish - basic Slavic group of languages (Serbian, Croatian, Bulgarian) – fluent |
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Participation in current projects |
Cvetkovski Aleksandar (Project member form N. Macedonia), 2019-ongoing COST EU-CA18112 - Mechanochemistry for Sustainable Industry https://www.cost.eu/actions/CA18112/#tabs|Name:overview Cvetkovski Aleksandar (Project member form N. Macedonia), 2019-ongoing COST EU-CA18202 - Network for Equilibria and Chemical Thermodynamics Advanced Researchhttps://www.cost.eu/actions/CA18202/#tabs|Name:overview Cvetkovski, Aleksandar (Project member from N. Macedonia) 2015-2018 COST Action CM1402 From molecules to crystals - how do organic molecules form crystals? (Crystallize). http://www.cost.eu/COST_Actions/cmst/CM1402 Cvetkovski, Aleksandar (Project member from N. Macedonia) 2017-ongoing European Network on Understanding Gastrointestinal Absorption-related Processes - UNGAP CA16205 http://www.cost.eu/COST_Actions/ca/CA16205
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Selected publications |
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Smilkov, Katarina and Gjorgieva Ackova, Darinka and Cvetkovski, Aleksandar and Ruskovska, Tatjana and Vidovic, Bojana and Atalay, Mustafa (2019) Piperine: Old Spice and New Nutraceutical? Current Pharmaceutical Design, 25 (15). pp. 1729-1739. ISSN 1873-4286 (Online) http://eprints.ugd.edu.mk/22694/ DOI: 10.2174/1381612825666190701150803 IF 2.2 Duvlis, Sotirija and Dabeski, Drage and Cvetkovski , Aleksandar and Mladenovska, Kristina and Plaseska‐Karanfilska, Dijana (2020) Association of TNF-a (rs361525 and rs1800629) with susceptibility to cervical intraepithelial lesion and cervical carcinoma in women from Republic of North Macedonia. The International Journal of Immunogenetics , 47 (6). pp. 522-528. ISSN 1744-313X http://eprints.ugd.edu.mk/26712/ IF 1.13 Cvetkovski, A; Ferretti, V; Bertolasi, V. New pharmaceutical salts containing pyridoxine, Acta Cryst. (2017). C73, 1064–1070 https://doi.org/10.1107/S2053229617015765 http://eprints.ugd.edu.mk/19088/ IF 6.2 Cvetkovski, A., Bertolasi, V., Ferretti, V., Supramolecular hydrogen-bonding patterns of co-crystals containing the active pharmaceutical ingredient (API) phloroglucinol and N-heterocycles, Acta Cryst. (2016). B72, 326-334; DOI: 10.1107/S2052520616004406 Cvetkovski, A., Ferretti, V., (2016) Crystal Structure and Packaging Analysis of Nitrofurantoin N,N-dimethylformamide Solvate, Crystallography Reports Volume 61, Issue 4, pp 611–615, ISSN 1063-7745 Gilli, Paola and Cvetkovski, Aleksandar (2016) Hydrogen-bonded cocrystals of the drug metformin: from molecular interactions analysis to supramolecular synthesis and characterization of Met-bis(DCA), a pharmaceutical cocrystal with enhanced anti-leukemic activity. Acta Crystallographica Section A, 72 (A72). p. 114. ISSN 2053-2733 Cvetkovski, Aleksandar (2020) The Challenge for Engineering Pharmaceutical Crystalline Solids: Scientific and Regulatory Affairs perspectives for crystal structure design and prediction. International Journal of Contemporary Research and Review, 11 . pp. 20201-20210. ISSN 0976-4852 Cvetkovskii A., Bettini R., Tasić Lj., Stupar M., Casini I., Rossi A., Giordano F., Thermal Properties of Binary Mixtures of β-cyclodextrin with Carbamazepine polymorphs, J. Therm. Anal. Cal. Vol. 68 (2002), 669-678 Cvetkovski, Aleksandar and Drakalska, Elena and Angelovska, Bistra (2018) Increasing water solubility, the prerequsite for improvement of bioavailability. "Acta Medica Balkanica", International Journal of Medical Sciences, 3 (5). pp. 9-12. ISSN 2545-4870 http://eprints.ugd.edu.mk/21864/ Cvetkovski, Aleksandar (2020) The Challenge for Engineering Pharmaceutical Crystalline Solids: Scientific and Regulatory Affairs perspectives for crystal structure design and prediction. International Journal of Contemporary Research and Review, 11 . pp. 20201-20210. ISSN 0976-4852 http://eprints.ugd.edu.mk/26711/ Drakalska, Elena and Angelovska, Bistra and Cvetkovski, Aleksandar and Stefanovska, Tamara (2018) Formulation and characterization of niosomes as potential nanocarriers for drug delivery. ,Acta Medica Balkanica"-International Journal of Medical Sciences, 3 (5). pp. 19-22. ISSN 2545-4870 http://eprints.ugd.edu.mk/21863/ Angelovska, Bistra and Drakalska, Elena and Gligorovska, Ana and Cvetkovski, Aleksandar (2018) Treatment of hypertension and complications in the Emergency Department-Delchevo. Knowledge - International Journal, Scientific Papers. ISSN 2545-4439 http://eprints.ugd.edu.mk/20880/ Gjorgieva Ackova, Darinka and Smilkov, Katarina and Cvetkovski, Aleksandar and Makreski, Petre (2020) Vibrational spectroscopy studies on biosynthesized silver nanoparticles. Macedonian Pharmaceutical Bulletin, 66 (S1). pp. 27-28. ISSN 1409 - 8695 http://eprints.ugd.edu.mk/26718/ Cvetkovski, Aleksandar and Gjorgieva Ackova, Darinka and Smilkov, Katarina and Drakalska, Elena and Duvlis, Sotirija and Angelovska, Bistra (2020) Пренаменети терапевтски индикации за метформин: стариот лек, со нови трикови во неговиот механизмот на дејство, нуди нови терапевтски апликации. Farmacevtski informator. ISSN 1409-8784 (In Press) http://eprints.ugd.edu.mk/id/eprint/26751 Cvetkovski, Aleksandar and Smilkov, Katarina and Gjorgieva Ackova, Darinka and Drakalska, Elena and Duvlis, Sotirija and Angelovska, Bistra (2020) Улога на интестиналните транспортери во унапредување на биорасположливоста на лековите. Farmacevtski informator. ISSN 1409-8784 (Submitted) http://eprints.ugd.edu.mk/id/eprint/26750
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Presentations |
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Aleksandar Cvetkovski, Elena Drakalska, Valerio Bertolasi, Valeria Ferretti. The role of proton transfer in multicomponent crystals of pyridine derivative with carboxylic acids (Poster), 10th Convention of Crystal Forms, 9-11 June, Bologna, Italy Aleksandar Cvetkovski, Darinka Gjorgieva Ackova, Katarina Smilkov, Petre Makreski. Screening for nutraceutical - drug interactions toward the non-covalent interactions of their solid binary systems (Case study on Piperine), Annual Conference of UNGAP-COST Action 16205, Sofia, 13-15 February 2019 Aleksandar Cvetkovski, Gjorgji Petruševski, Ljupčo Pejov, Monika Stojanovska, Sonja Ugarkovic, Petre Makreski, Solid-state characterization of the molecular salts of Pyrodoxine, (Poster), 25th Conference of Serbian Crystallographic Society, 22-23 June, 2018, Bajna Basta, Serbia (Poster) https://skd.org.rs/wp-content/uploads/2018/06/Conference-Program_SKD_2018_BB.pdf Cvetkovski Aleksandar, Smilkov Katarina, Georgieva-Ackova Darinka, “Preliminary study on screening of the intermolecular interactions of organic cation drugs from BCS III: Metformin Case Study, Poster, 07-09.03.2018, Leuven Belgium, conference on „INTESTINAL ABSORPTION: WHAT IS HAPPENING INSIDE AND BEYOND”, part of EU-COST CA16205 project: European Network on Understanding Gastrointestinal Absorption-related Processes, https://gbiomed.kuleuven.be/english/research/50000715/50000716/ungap/wg-meeting-march-2018-1 Cvetkovski Aleksandar, Bertolasi Valerio, Gilli Paola, Pseudo-polymorphic forms of new molecular salts of the antiplated drug with thienopyridine structure S(+)Clopidogrel Pseudo-polymorphic forms of new molecular salts of the antiplated drug with thienopyridine structure S(+)Clopidogrel, Poster, 8th Crystal Form Convention, Bologna, 4-6 Juni, 2017, Italy (Poster) http://eprints.ugd.edu.mk/19095/ Cvetkovski, Aleksandar and Drakalska, Elena (2017) Increasing water solubility of drugs, the prerequisite for improvement of bioavailability. In: Second International Scientific Conference of the Faculty of Medical Sciences - SISCFMS 2017, 06-08 Oct 2017, Tetovo, Macedonia. http://eprints.ugd.edu.mk/18401/ Drakalska, Elena Angelovska Bistra, Cvetkovski Aleksandar, Stefanovska, Tamara (2017) Formulation and characterization of niosomes as potential nanoparticles for drug delivery. In: Second International Scientific Conference of the Faculty of Medical Sciences - SISCFMS 2017, 06-08 Oct 2017, Tetovo, Macedonia http://eprints.ugd.edu.mk/18400/ Cvetkovski, A., Angelovska, B., The role of cocrystallization screening for the assessment of structure-activity relationship in drug development" Oral Presentation, 6th Congress of Pharmacy in Macedonia, 3rd June, 2016 Cvetkovski Aleksandar “The role of molecular cocrystals in drug development”, Oral Presentation, Scientific Symposium on "Current achievements and future perspective in medical and biomedical research.", 24th Novembre, Stip, Macedonia http://js.ugd.edu.mk/index.php/ISMS Cvetkovski Aleksandar, Gilli Paola, Bertolasi Valerio, “Pharmaceutical Cocrystals of Metformin”, Poster, 1st European School of Crystallography, Pavia, Italy August 28- Spetember 6, 2014, Cvetkovski Aleksandar, Gilli Paola, Bertolasi Valerio, “Pharmaceutical Cocrystals of Biguanide Drugs: Metformin”, Poster, La XIII Giornata della Chimica dell'Emilia Romagna, il Bologna, 18 Dicembre 2013 Cvetkovski Aleksandar, Gilli Paola, Bertolasi Valerio, “Preliminary Screening of Cocrystallization of Methylxanthine Class of Drugs:Pentoxyphylline and Caffeine”, Poster, La XIII Giornata della Chimica dell'Emilia Romagna Ferrara il 17 Dicembre 2012 Cvetkovski Aleksandar, Gulaboski Rubin, “ Engineering of Pharmaceutical co-crystals”, From Molecules to Functionalised Materials, SOE-DAAD Workshop Skopje, 16-20 March 2011. Aleksandar Cvetkovski , Ljiljana Tasic, Ruggero Bettini and Fernando Giordano, Influence of Cyclodextrin on the crystallinity and dissolution rate of carbamazepine polymorphs (5th Central European Symposium on Pharmaceutical Technology and Biotechnology, organized by EUFEPS-European Federation for Pharmaceutical Sciences and Controlled Release Society) September 25-27, 2003, Aleksandar Cvetkovski Preformulation Study of Pseudopolimorph form of Carbamazein and Influence of beta-Cyclodextrin on Phase Transition, Master of Science Thesis, Defended at the Faculty of Pharmacy, University in Belgrade, Serbia, 200 Cvetkovski A., TasićLj., Stupar M., Plenary Lecture “Approach for Selection of Methods for Characterization of the Pharmaceutical Solids”, published in Archive for Pharmacy (Proceeding Book), no.4, pp. 536, Third Yugoslav Congress of Pharmacy with international participation, Belgrade, Yugoslavia, 29th October-2nd November, 2002 Lj.Tasic, A.Cvetkovski, J.Milic, Title: Preformulation studies of solid dosage forms: Choice and selection of methods for polymorphic drug (XIV Hungarian Conference on Pharmaceutical Technology, 8/10 November,2002, Heiviz (Hungary). Cvetkovski A; Influence of Binder Solution in Wet Granulation Process on Properties of Propranolol Tablets, Proceeding Book of the 16th Congress of Chemists and Technologists of Macedonia (with international participation), Volume 1, Faculty of Technology and Metallurgy, Skopje, 28-30 October, 1999, pp.311-313.) Cvetkovski, A, Technology Transfer through Spin - Off Companies - from Academic Research to Commercialization in the Life Science Sectors, 4th International Conference for Entrepreneurship, Innovation and Regional Development From Entrepreneurial Learning to Innovation and Regional Development, 5 – 7 May 2011, Ohrid, Macedonia A. Cvetkovski, V. Zah, Pharmacoeoconomics& Outcomes Research Perspectives in Health Care Sector, Fourth Congress of Pharmacy of Macedonia with International Participation, 26-30 September, Ohrid, 2006. A. Cvetkovski, Technology Transfer through Spin-off Companies: From Academic Research to Commercialization. Invited speaker at the Seminar for Continuing Education and Post-graduated studies for pharmacists. In organization of Pharmaceutical Center for Continuing Education and Faculty of Pharmacy, Belgrade, May, 2007 TasicLj., Cvetkovski A., Marinkovic V., KNOWLEDGE MANAGEMENT AS A TOOL IN PHARMA BUISINESS, Proceeding Book of 4th International Working Conference TOTAL QUALITY MANAGEMENT – ADVANCED AND INTELLIGENT APPROACHES, May 27th – 30th 2007, Belgrade SERBIA A. Cvetkovski, “Technology Transfer in Knowledge Based Industries, Pharmaceutical Sector as an Example”, invited speaker, 2nd Technology Transfer Conference & Exhibition, Bahrain, December, 2006 Total Quality Management-ICN Pharmaceuticals’ Training Seminar, Belgrade, 1997 Cvetkovski A; “GMP Preconditions for Quality in Pharmaceutical industry”, Oral Presentation, TQM (Total Quality Management) Symposium, organized by Macedonian Quality Association and Macedonian Trade Chamber, Macedonia 1997 Cvetkovski, Aleksandar and Angelovska, Bistra (2016) The role of cocrystallization screening for the assessment of structure-activity relationship in drug development. Macedonian pharmaceutical bulletin, 62. pp. 345-346. ISSN 1409 - 8695 http://eprints.ugd.edu.mk/id/eprint/17054 Ivanovska, Verica and Cvetkovski, Aleksandar (2010) Терапија со лекови кај гравидни жени. Фармацевтски информатор, 9 (23). pp. 36-38. ISSN 1409-8784 http://eprints.ugd.edu.mk/id/eprint/15886 Cvetkovski, Aleksandar (2010) Фармацевтски производи за примена кај педијатриски пациенти. Фармацевтски информатор, 9 (23). pp. 39-40. ISSN 1409-8784 http://eprints.ugd.edu.mk/id/eprint/15887
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Book Cvetkovski, Aleksandar (2011) Troškovi, kvalitet i ishodi zdravstvene zaštite : ISPOR knjiga termina. In:
Troškovi, kvalitet i ishodi zdravstvene zaštite: ISPOR knjiga termina. Beograd: Udruženje ISPOR Srbija. ISBN 978-86-912363-1-1 http://eprints.ugd.edu.mk/id/eprint/15629
Social
Activities Representative to PhD Students to the University in Ferrara Assembly for social security and
family issues of postgraduate students/ researchers (2012-2014), Ferrara, Italy