Results from the Coenzyme Q-0 project in the first year
PROJECT TITLE: Metal binding and antioxidative properties of novel Coenzyme Q-0 derivatives/Металокомплексирачки и антиоксидативни својства на нови деривати на Коензим Q-0
In this project we focus on synthesizing new derivatives of Coenzyme Q-0 by its reaction in alkaline media. The identification of the reaction products is achieved via chromatographic methods, while their redox, metal-binding and antioxidative properties are evaluated by using voltammetric and EPR (Electron paramagnetic resonance) technique. A Master thesis is due to be defended from the topic elaborated in this project. All the derivatives synthesized in this project are potential antioxidants and metal-ion ligands, while showing high potential toward eliminating various reactive oxygen species. Their potential application in pharmacy and medicine is currently investigated.
Research team: Prof. Rubin Gulaboski, Prof. Liljana Koleva Gudeva, Doc Violeta Ivanova Petropulos, Doc. Sanja Kostadinovik, prof. Valentin Mirceski, Doc. Ivan Bogeski, Prof. Reinhard Kappl, Prof. Markus Hoth, prof. Sasa Mitrev
Papers related to the project, published in international journals with Impact Factor:
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Rubin Gulaboski, Ivan Bogeski, Valentin Mirčeski, Stephanie Saul,Bastian Pasieka, Haleh H. Haeri, Marina Stefova, Jasmina Petreska Stanoeva, Saša Mitrev, Markus Hoth, Reinhard Kappl, "Hydroxylated derivatives of dimethoxy-1,4-benzoquinone as redox switchable earth-alkaline metal ligands and radical scavengers"Nature Scientific Reports, 3 (2013) 1-8,
doi:10.1038/srep01865,http://www.nature.com/srep/2013/130521/srep01865/full/srep01865.html
2. Valentin Mirceski, Rubin Gulaboski, Milivoj Lovric, Ivan Bogeski, Reinhard Kappl and Markus Hoth, Square-Wave Voltammetry: A Review on the Recent Progress, Electroanalysis 25 (2013) pages 2411–2422. DOI: 10.1002/elan.201300369.
3. Valentin Mirceski,
- Angela Aleksovska,
- Biljana Pejova,
- Vladimir Ivanovski,
- Biljana Mitrova,
- Nikolina Mitreska,
- Rubin Gulaboski, "Thiol anchoring and catalysis of Gold nanoparticles at the liquid-liquid interface of thin-organic film modified electrodes",Electrochem Commun. 2013
- doi: 10.1016/j.elecom.2013.11.020
- 4. Rubin Gulaboski, Valentin Mirceski, Sasa Mitrev, Development of a rapid and simple voltammetric method to determine the total antioxidative capacity of edible oils, Food Chemistry 138 (2013), 116-121 doi 10.1016/j.foodchem.2012.10.050 http://0-www.sciencedirect.com.precise.petronas.com.my/science/article/pii/S0308814612015889?v=s5
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Rubin Gulaboski, Ivan Bogeski, Valentin Mirčeski, Stephanie Saul,Bastian Pasieka, Haleh H. Haeri, Marina Stefova, Jasmina Petreska Stanoeva, Saša Mitrev, Markus Hoth, Reinhard Kappl, "Hydroxylated derivatives of dimethoxy-1,4-benzoquinone as redox switchable earth-alkaline metal ligands and radical scavengers"Nature Scientific Reports, 3 (2013) 1-8, doi:10.1038/srep01865,http://www.nature.com/srep/2013/130521/srep01865/full/srep01865.html
- Valentin Mirceski, Rubin Gulaboski, Milivoj Lovric, Ivan Bogeski, Reinhard Kappl and Markus Hoth, Square-Wave Voltammetry: A Review on the Recent Progress, Electroanalysis 25 (2013) pages 2411–2422. DOI: 10.1002/elan.201300369.
- Valentin Mirceski,
- Angela Aleksovska,
- Biljana Pejova,
- Vladimir Ivanovski,
- Biljana Mitrova,
- Nikolina Mitreska,
- Rubin Gulaboski, "Thiol anchoring and catalysis of Gold nanoparticles at the liquid-liquid interface of thin-organic film modified electrodes", Electrochem Commun. 2013
- doi: 10.1016/j.elecom.2013.11.020
- Rubin Gulaboski, Valentin Mirceski, Sasa Mitrev, Development of a rapid and simple voltammetric method to determine the total antioxidative capacity of edible oils, Food Chemistry 138 (2013), 116-121 doi 10.1016/j.foodchem.2012.10.050 http://0-www.sciencedirect.com.precise.petronas.com.my/science/article/pii/S0308814612015889?v=s5